Work

Acquired narcolepsy secondary to a presumptive hypothalamic hamartoma in a young German wirehaired pointer dog

Year: 2025

Type: article

Abstract: A 3‐year‐old, male, entire, German wirehaired pointer dog was presented with a 2‐year history of paroxysmal episodes of collapse associated with reduced levels of consciousness. A magnetic resonance imaging study identified a single, ill‐defined, non‐contrast‐enhancing, intra‐axial mass lesion involving the hypothalamus. Cerebrospinal fluid levels of hypocretin (orexin) neuropeptide were below normal, consistent with a disease process affecting the sleep–wake cycle. The dog was diagnosed with suspected acquired narcolepsy secondary to a presumptive hypothalamic hamartoma. Treatment with imipramine resulted in reduced frequency and severity of the episodes.

Source: Veterinary Record Case Reports

DOI: 10.1002/vrc2.70086

Authors: Callum Atkins, Tessa V. Procter, Tobias Schwarz, Megan Madden

Institution: University of Edinburgh

Language: English

Topic: Sleep and Wakefulness Research

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,480