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AgOTf‐Catalysed Regioselective C1‐Amination of Pyrrolo[1,2‐a]quinoxaline With Azodicarboxylates

Year: 2025

Type: article

Abstract: ABSTRACT AgOTf‐catalysed regioselective C1‐amination of pyrrolo[1,2‐a]quinoxaline has been developed. The reaction allowed the use of various pyrrolo[1,2‐a]quinoxalines and azodicarboxylates as coupling partners to afford C1‐aminated products with good to excellent yields. The synthetic strategy showed excellent regioselectivity, functional group tolerance as well as gram‐scale synthesis. The amination products were further modified to furnish structurally diverse pyrrolo[1,2‐a]quinoxaline compounds.

Source: Applied Organometallic Chemistry

DOI: 10.1002/aoc.70228

Authors: Wanqiang Wang, Jing Guo, Di Hao, Yishi Guo, Jianshu Zhang, Ping Liu

Institution: Shihezi University

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: National Natural Science Foundation of China

Award: G3618777180