Early-Onset Corticobasal Degeneration: A Case of Rapidly Progressive Dementia with primary Progressive Aphasia and Severe Behavioral Disturbances
Year: 2025
Type: article
Study design: Case Report
Abstract: Corticobasal degeneration (CBD) is a rare neurodegenerative disorder with diverse clinical manifestations, often overlapping with other conditions like Alzheimer’s and frontotemporal dementia. We present the case of a 35-year-old male with early-onset CBD, characterized by rapidly progressive dementia, primary progressive aphasia, and severe behavioral disturbances. Initial imaging revealed left temporal lobe atrophy and right vertebral artery hypoplasia, progressing to significant cortical atrophy in the temporal and frontal lobes within a year. Despite extensive diagnostic evaluations and symptomatic treatments, including Donepezil and Memantine, the patient’s condition deteriorated rapidly. This case underscores the challenges of diagnosing and managing CBD, particularly in young patients, and highlights the urgent need for improved diagnostic tools and effective therapies.
Source: JUNIOR RESEARCHERS
Institution: Tbilisi State Medical University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410521909