Bioregenerative autologous scaffold made from bone marrow aspirate concentrate, cancellous bone autograft, platelet-rich plasma, and autologous fibrin to treat non-unions of the femur, humerus, and forearm bones: a case series
Year: 2025
Type: article
Study design: Case Report
Abstract: AIM: To evaluate the effectiveness of a bioregenerative scaffold created from bone marrow aspirate, cancellous bone autograft, platelet-rich plasma, and autologous fibrin in treating complicated non-unions of the supracondylar femur, humeral shaft, and radius and ulna. METHODS & MATERIALS: Three patients with non-unions resulting from multiple surgical failures underwent bone stabilization along with the application of a novel bioregenerative scaffold. X-rays and subjective assessments were collected prior to surgery and at 6- and 12-months post-surgery. RESULTS: All non-unions demonstrated healing with adequate callus formation, as confirmed by radiological assessments. By 12 months, all patients were able to resume full weight-bearing activities or regain full range of motion and physical strength without pain. Statistical analysis revealed improvements across all assessment scales compared to pre-surgical values. CONCLUSION: This approach offers a viable option for treating complex long bone non-unions after multiple surgical interventions.
Source: Regenerative Medicine
Authors: Dulic Oliver, Abazovic Dzihan, Obradovic Mirko, Vranjes Miodrag, Lalic Ivica, Ninkovic Srdjan, Rasovic Predrag, Bjelobrk Mile, Baljak Branko, Milinkov Milan, Tosic Milan, Sarac Srdjan
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4410522140