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Refractory Primary Duodenal Plasmacytoma Displaying t(11;14): A Report of a Rare Case

Year: 2025

Type: article

Abstract: Extramedullary plasmacytoma (EMP) involving the digestive tract is a very rare entity that represents only a very small fraction of multiple myeloma (MM) cases. We describe an unusual case of a 71-year-old man with EMP involving the duodenum who initially presented to the emergency room with melena. The final diagnosis was duodenal plasmacytoma with t(11;14), and the diagnosis was reached by fibroscopy with biopsy and immunohistochemistry (IHC). The patient received local radiotherapy and showed failure three months after treatment. Then, he was administered daratumumab-based treatment associated with Revlimid and dexamethasone (DRD). To our knowledge, this is the first report showing duodenal involvement by EMP with t(11;14).

Source: Cureus

DOI: 10.7759/cureus.84443

Authors: Nora El Maachi, Marlene Ochmann, Claire Belchet

Institution: Centre hospitalier universitaire d'Orléans

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4410526115