Comparison of Intravenous Carbetocin (100 Mcg) and Intravenous Oxytocin (10 IU) for the Prevention of Postpartum Hemorrhage Following Emergency Cesarean Section
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: BACKGROUND: Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality, particularly following cesarean sections. While oxytocin is the standard uterotonic agent, carbetocin, a long-acting synthetic analogue, may offer improved efficacy due to its prolonged uterotonic effect and better stability. OBJECTIVE: This study aimed to compare the effectiveness of intravenous carbetocin (100 mcg) versus oxytocin (10 IU) in preventing PPH following emergency cesarean sections by evaluating blood loss, the need for additional uterotonics, and maternal hemodynamic stability. MATERIALS AND METHODS: A total of 350 women undergoing emergency cesarean section were randomly assigned to receive either carbetocin (Group A) or oxytocin (Group B). Intraoperative blood loss, uterine tone, and hemodynamic parameters were measured. Statistical analysis was performed using IBM SPSS Statistics software, version 26 (IBM Corp., Armonk, NY). RESULTS: Carbetocin was associated with significantly lower blood loss ≥1000 ml (13(7.43%) vs. 33(18.86%), p = 0.0015) and a reduced need for additional uterotonics (10(5.71%) vs. 21(12%), p = 0.0385). Uterine tone was superior in the carbetocin group at three and five minutes post-administration (p = 0.023 and p = 0.003, respectively). Both drugs had similar safety profiles, with no significant differences in adverse effects. CONCLUSION: Carbetocin demonstrated superior efficacy in preventing PPH compared to oxytocin, with lower blood loss, reduced need for additional interventions, and improved uterine tone. Carbetocin is a viable and safer alternative to oxytocin for PPH prevention, especially in emergency cesarean sections.
Source: Cureus
DOI: 10.7759/cureus.84426
Authors: Vadlamudi Keerthi Chowdary, Subhashchandra R Mudanur, Rajasri G Yaliwal, Shreedevi Kori, Ekta Chhabra
Institutions: Shri BM Patil Medical College, BLDE (Deemed to be University)
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410527770