Work

BRAFV600E augments WNT signaling in colorectal cancer via aberrant DNA methylation

Year: 2025

Type: article

Abstract: enhances WNT pathway activation through modulation of DNA methylation patterns.

Source: iScience

DOI: 10.1016/j.isci.2025.112708

Authors: Layla El Bouazzaoui, Jeroen M. Bugter, Emre Küçükköse, André Verheem, Jasmin B. Post, Nicola Fenderico, Inne H.M. Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg

Institutions: Utrecht University, University Medical Center Utrecht, Oncode Institute

Language: English

Topic: Wnt/β-catenin signaling in development and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: ZonMw, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, KWF Kankerbestrijding, Oncode Institute, Topconsortium voor Kennis en Innovatie

Awards: G4857045484, G5533858857, Hoe leiden erfelijke LKB1 mutaties tot een vergrote kans op darmkanker?

OpenAlex ID: W4410529997

FWCI: 0.253

Cites: 65

Cited by: 1

Related to: 10