Work

Pseudo-Thrombotic Microangiopathy (Pseudo-TMA): a rare manifestation of vitamin B12 deficiency in a child

Year: 2025

Type: article

Abstract: Vitamin B12 is vital for physiological functions, and its deficiency can manifest from mild symptoms to severe conditions. This case report discusses a rare presentation of Vitamin B12 deficiency as Pseudo-Thrombotic Microangiopathy (Pseudo-TMA) in an 11-year-old vegan child. Pseudo-TMA, marked by hemolytic anemia, thrombocytopenia, and schistocytosis, mimics thrombotic microangiopathy (TMA) and requires accurate diagnosis. A thorough history, examination, and targeted investigations revealed severe macrocytic anemia with pancytopenia. Macrocytic anemia with reticulocytopenia is a common form of megaloblastic anemia in developing countries. Management included stabilization with blood transfusion, parenteral vitamin B12, and oral multivitamins. The favorable response highlights the importance of clinical evaluation in diagnosing rare pediatric presentations and optimizing resource use.

Source: Pediatric Hematology Oncology Journal

DOI: 10.1016/j.phoj.2025.100455

Authors: Mohd Arif, Nazish Malik

Institution: Career Institute Of Medical & Dental Sciences and Hospital

Language: English

Topic: Folate and B Vitamins Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600