Work

Modeling COPD in Drosophila melanogaster by cigarette smoke inhalation: functional changes and alterations in the expression of COPD-relevant orthologous genes

Year: 2025

Type: article

Abstract: Inhalation exposure of adult D. melanogaster to cigarette smoke induced changes in physiological parameters and the expression of COPD-associated orthologous genes. Transcriptomic responses were more profound in females, indicating sex-specific responses to inhaled toxicants. Furthermore, enrichment analyses of the differentially expressed genes in females pointed to biomolecules associated with response to nicotine and detoxification. D. melanogaster thus provides a powerful model system to test the efficacy of new potential drugs for COPD treatment.

Source: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI: 10.1152/ajpregu.00056.2025

Authors: Periklis Marnas, Stefan Lüpold, Lydia Giannakou, Athanasios-Stefanos Giannopoulos, Chrissi Hatzoglou, Konstantinos I. Gourgoulianis, Sotirios G. Zarogiannis, Erasmia Rouka

Institutions: University of Thessaly, University of Zurich

Language: English

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4410538209

FWCI: 1.191

Cites: 25

Cited by: 2

Related to: 10