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The effect of fecal microbial transplantation in a pediatric patient after 28 episodes of febrile urinary tract infection

Year: 2025

Type: article

Abstract: Recurrent febrile urinary tract infections (fUTIs) in children can lead to serious complications such as renal scarring and progressive chronic kidney disease (CKD), with growing evidence indicating that gut microbiome dysbiosis may play a key role in their development. Fecal microbial transplantation (FMT) is an established therapeutic approach for restoring gut microbial balance; however, its use in patients with recurrent fUTIs remains limited and underexplored. This case study describes a 10-year-old boy with recurrent fUTIs and CKD secondary to a posterior urethral valve (PUV) anomaly. The patient was administered a total of seven doses of FMT. FMT reduced pathogenic Enterobacteriaceae, increased beneficial short-chain fatty acid (SCFA)-producing genera, and correspondingly raised SCFA levels, indicating restoration of gut microbiota balance. FMT presents an innovative therapeutic option for pediatric patients with recurrent fUTIs, demonstrating outstanding clinical outcomes.

Source: Pediatric Nephrology

DOI: 10.1007/s00467-025-06822-1

Authors: Barbora Piteková, Ivan Hric, Eva Baranovičová, Jakub Zieg, Paul J. Planet, Viktor Bielik