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Mineralizing angiopathy: A cause of arterial ischemic stroke in early childhood after mild head trauma

Year: 2025

Type: article

Abstract: INTRODUCTION: Mineralizing angiopathy of lenticulostriate arteries has been reported as etiology of acute arterial ischemic stroke of basal ganglia after minor head trauma, mostly in infants. Patients present with focal neurological deficit, commonly hemiparesis, minutes to hours after head trauma. Diagnostic clue is the finding of ischemic stroke of basal ganglia after minor head trauma together with basal ganglia calcifications. RESULTS: We present a 21-month-old infant with an acute right hemiparesis preceded by mild head trauma 8h before. Neuroimaging studies showed an ischemic stroke of left basal ganglia together with bilateral basal ganglia calcifications. Other ancillary studies were normal. The patient received treatment with acetylsalicylic acid for antiplatelet therapy. Prognosis was excellent, he recovered the focal neurological deficit, and no recurrences nor neurological sequelae were found after a 6year follow-up. CONCLUSIONS: A high index of suspicion is necessary to identify mineralizing angiopathy of lenticulostriate arteries as etiology of an acute arterial ischemic stroke of basal ganglia after minor head trauma in early infancy. Stroke recurrence is possible.

Source: Neurología (English Edition)

DOI: 10.1016/j.nrleng.2025.05.003

Authors: G. Prieto-Berchez, M.T. González-Campillo, J. Vicente-Rueda, E. López-Laso

Institutions: Hospital Universitario Reina Sofía, Hospital General Universitario de Ciudad Real, Instituto Maimónides de Investigación Biomédica de Córdoba, Centre for Biomedical Network Research on Rare Diseases

Language: English

Topic: Neurological and metabolic disorders

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,034