Work

Topical administration of tranexamic acid for prevention of postoperative epidural fibrosis: insights from a rabbit laminectomy model.

Year: 2025

Type: article

Abstract: TXA solution applied topically to the laminectomy site, while the control group received 5.00 mL of saline. Postoperative evaluations included magnetic resonance imaging at week six to assess EF, followed by histopathological examinations to evaluate fibroblast cell density in scar tissue, EF grading and thickness of the dura mater. The analysis of magnetic resonance imaging and histopathologic data revealed significant differences between the two groups indicating that topical administration of TXA might be a promising approach for preventing EF.

Source: PubMed

DOI: 10.30466/vrf.2024.2031220.4312

Authors: Arian Rahmani, Soroush Mohitmafi, Fariborz Moayer, Mohammad Molazem

Institutions: Islamic Azad University, Karaj, University of Tehran

Language: English

Topic: Spine and Intervertebral Disc Pathology

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Brain Mapping Laboratory, Tehran University of Medical Sciences and Health Services