Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: While prognostic and predictive factors in breast cancer are well established, data on aggressive behavior in luminal A subtype breast cancers are limited. The aim of this study was to investigate histomorphological and clinicopathological parameters that may predict treatment resistance and aggressive behavior in luminal A subtype, as well as the expression of two key proteins, PTEN and p53, involved in breast carcinoma development. Materials and Methods: We included breast carcinoma cases diagnosed at a Turkish University Hospital between 2016 and 2017. Tumor tissue with internal control was available for all cases. PTEN and p53 expression were evaluated immunohistochemically, based on staining strength and percentage. Results: <0.05). Conclusion: PTEN loss, observed in all recurrent luminal A cases and 77.1% of all cases, supports its role as a tumor suppressor. The findings suggest that PTEN expression loss may be a prognostic marker, and immune-modulating treatments should be considered for breast cancer patients.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4410548649