Work

Alliin from garlic as a neuroprotective agent attenuates ferroptosis in vitro and in vivo via inhibiting ALOX15

Year: 2025

Type: article

Abstract: . In conclusion, our study highlights ALOX15 as a critical factor in ferroptosis associated with ICH, and shows that alliin exerts neuroprotective effects by inhibiting ALOX15-dependent ferroptosis.

Source: Food & Function

DOI: 10.1039/d5fo00425j

Authors: Junjun Meng, Chengquan Wen, Yang Lu, Xiaofan Fan, Ruili Dang, Jianfeng Chu, Pei Jiang, Wenxiu Han, Lei Feng

Institutions: Jining First People's Hospital, Shandong First Medical University, Qingdao Eighth People's Hospital, Jining Medical University

Language: English

Topic: Ferroptosis and cancer prognosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation, Natural Science Foundation of Shandong Province, China International Medical Foundation

Awards: G1580581902, G4977125512, G5802050048, G8196707921

OpenAlex ID: W4410550730

FWCI: 7.898

Cites: 55

Cited by: 13

Related to: 10