Work

Enantioselective synthesis of spiro[indoline-3,1′-pyrazolo[1,2- b ]phthalazine] derivatives via an organocatalytic three-component cascade reaction

Year: 2025

Type: article

Abstract: ]phthalazine] derivatives was first developed through an organocatalysed cascade Knoevenagel/Michael/cyclization reaction using a quinidine-derived squaramide. Under the optimized conditions, the three-component reaction of isatins, malononitrile (cyanoacetate) and phthalhydrazide yields the desired pyrazolophthalazinyl spirooxindoles in good yields (73-90%) with up to >99% enantiomer excess (ee).

Source: RSC Advances

DOI: 10.1039/d5ra01633a

Authors: Luying Song, Yuhong Sun, Renbo An, Liming Wang, Ying Jin

Institutions: Yanbian University, Jilin Medical University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funders: People's Government of Jilin Province, Education Department of Jilin Province