Research Advances on the Molecular Mechanisms of Porphyromonas gingivalis in Promoting Oral Squamous Cell Carcinoma Progression
Year: 2025
Type: article
Abstract: 牙龈卟啉单胞菌(Porphyromonas gingivalis, Pg)作为牙周病的主要致病菌，近年被证实与口腔鳞状细胞癌(OSCC)的发生、发展及预后密切相关。Pg通过炎症微环境、免疫逃逸、代谢重编程等机制促进OSCC发展。本文综述了Pg参与OSCC进展的分子机制，为OSCC的治疗策略提供理论依据。P. gingivalis, a primary pathogenic bacterium in periodontitis, has been increasingly implicated in the onset, progression, and prognosis of oral squamous cell carcinoma (OSCC). Porphyromonas gingivalis promotes the development of OSCC through mechanisms including inflammatory microenvironment modulation, immune escape, and metabolic reprogramming. This review summarizes the molecular mechanisms by which P. gingivalis contributes to OSCC development, providing a theoretical basis for therapeutic strategies against OSCC.
Source: Advances in Clinical Medicine
Author: 军 杨
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4410567927