Gastrointestinal and Biochemical Characteristics in Dyspeptic Patients with Anaphylaxis: A Comparative Study
Year: 2025
Type: article
Study design: Observational Study
Abstract: The objective of this study was to evaluate the gastrointestinal and biochemical characteristics of dyspeptic patients with documented drug allergies in comparison to a control group of dyspeptic patients without drug allergies.By e xamining the demographic data, blood haemogram, biochemical parameters, and gastric antrum biopsy results, we sought to gain further insight into the impact of drug-induced anaphylaxis on these patients.A total of 122 patients presenting with dyspeptic symptoms and documented drug allergies, who were referred to gastroenterology outpatient clinics from internal medicine and general surgery outpatient clinics, were included in the analysis.A control group of 100 dyspeptic patients without drug allergies was also included for comparison.The demographic data, blood haemogram, biochemical parameters, and gastric antrum biopsy results ( Helicobacter pylori, intestinal metaplasia, atrophy) were collected and subjected to analysis.Statistical comparisons were conducted between the anaphylaxis group and the control group, as well as within the anaphylaxis group itself.The study included 122 patients with drug allergies (73.8% female, mean age 53.12±15.73years) and 100 controls.No significant differences were identified in the prevalence of Helicobacter pylori, metaplasia, or atrophy across different allergy types.However, patients with a cephalosporin allergy exhibited significantly elevated calcium levels in comparison to individuals with other allergy types (p<0.05).In comparison to the control group, the anaphylaxis group was characterised by a higher proportion of females, a lower mean age, and higher leukocyte and lymphocyte values.It can be concluded that dyspeptic patients with drug-induced anaphylaxis exhibit distinct gastrointestinal and biochemical characteristics in comparison to those without drug allergies.These findings emphasise the necessity for tailored clinical management and further research into the underlying mechanisms driving these differences.
Source: Eastern Journal Of Medicine
Authors: Sefer Aslan, Ersin Kuloğlu, Ali Muhtaroğlu, Kubilay İşsever, Gökhan Aydın, Eray Beşirli, Ahmet Cumhur Dülger
Institution: Giresun University
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410568371