Year: 2025
Type: article
Abstract: Neutron Capture Therapy (NCT) for cancer treatment is experiencing renewed interest due to advancements in accelerator-based neutron beams, treatment planning software, and patient positioning devices. This study presents the repurposing of an existing neutron radiography beamline (Dingo), at the OPAL research nuclear reactor, for radiobiological research and novel NCT development. Human glioblastoma cell cultures were irradiated for up to 10 mins with a flux of 2.57x108 n/cm2⋅s (± 2.73x107) and the resulting impact was quantified by assessing DNA damage by both immunocytochemistry and flow cytometry. This low cost methodology extends the capability of an existing beamline to allow the development of novel neutron capture agents and study of neutron radiobiological mechanisms. Increasing availability of neutron sources for biological study in this fashion will accelerate the development of NCT for disease specific clinical application.
Source: Scientific Reports
Language: English
Topic: Boron Compounds in Chemistry
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W4410588028