Year: 2025
Type: article
Abstract: Introduction: Hemostasis in parenchymal organs remains an issue in abdominal surgery. Effective hemostasis in modern operating rooms is achieved by various local hemostatic agents, which are often composite. Objective: To investigate structural characteristics of novel composite hemostatic sponges. Materials and methods: We compared samples of novel hemostatic sponges (with different weight ratios [15:85, 25:75, and 50:50] of marine collagen to sodium carboxymethylcellulose [Na-CMC]) developed by our team with local hemostatic agents used in clinical practice. There was a total of 7 study groups. All the samples were studied in transmitted light and underwent microphotography with subsequent morphometry. We performed scanning electron microscopy and measured fiber thickness (μm) and pore area (mm2). Results: The largest pore areas were found in the group of samples developed by our team (with the lowest content of marine collagen, 15%), which was higher than in groups with sponges already introduced into clinical practice (1.5 times higher compared with groups 4 and 7 and 2.7 times higher than in group 6). In terms of fiber thickness, the highest values were observed in group 3 (Na-CMC/marine collagen ratio of 50:50). Conclusions: The optimal ratio of collagen/Na-CMC in hemostatic sponges is 50:50, resulting in sufficient porosity and fiber thickness. Owing to these structural characteristics the sample demonstrated its high efficacy in animal studies.
Source: Innovative medicine of Kuban
Institutions: Kursk State Medical University, Kursk State University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410589580