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Characteristics and Outcomes of Children and Adolescents With Epithelial Ovarian Neoplasms From a Tertiary Cancer Centre in Western India: A Retrospective Study

Year: 2025

Type: article

Abstract: Epithelial ovarian neoplasms (EON) are uncommon in children and data is limited. We conducted this study to assess the clinical characteristics and outcomes of children and adolescents with EON. Children ≤18 years of age diagnosed with EON, between 1st January 2010 and 31st December 2022 were included for retrospective analysis. Clinical characteristics, treatment details, and outcomes were noted. One-hundred-sixteen patients were diagnosed with ovarian mass, and eight (0.07%) of them were EON. Median age was 17 years (range: 13-18 years). One (12.5%) patient had a family history of breast cancer. One (12.5%) had borderline serous cystadenocarcinoma, four (50%) had malignant serous, and three (37.5%) had malignant mucinous adenocarcinoma. One girl with borderline disease (stage Ia) was treated with surgery and is alive. Among seven patients with malignant EONs, two (28.6%), two (28.6%), two (28.6%), and one (14.2%) had stage Ia, II, IIIc, and Iva disease, respectively. Two (28.6%) patients underwent primary debulking surgery. Two patients (28.6%) received neoadjuvant chemotherapy (NACT) followed by interval debulking. Three (42.8%) patients received chemotherapy and did not undergo surgery because of stable/progressive disease. Two patients (25%) with stage Ia were alive without evidence of disease. One girl (12.5%) with stage IIb relapsed after primary treatment and succumbed to the disease. All three patients with stage IIIc and one with stage IVa had relapse/progression, and three patients succumbed to the disease. Malignant EONs require multimodality treatment. Advanced disease and serous tumors are associated with poor survival. With a mean (± standard deviation) follow-up of 56 ± 10 months, the three-year progression-free survival (PFS) and overall survival (OS) were 37.5%±17.1% and 70%±18.2%, respectively.

Source: Cureus

DOI: 10.7759/cureus.84650