Work

Risk factors and clinical outcomes in patients with colistin-resistant Klebsiella pneumoniae bloodstream infection: A retrospective analysis

Year: 2025

Type: article

Abstract: PURPOSE: Increase in the incidence of colistin-resistant K. pneumoniae (ColR) necessitates the study of risk factors responsible for its emergence. The current study aims to investigate the risk factors and clinical outcomes in ColR patients. MATERIAL AND METHODS: A retrospective study was conducted at a tertiary care hospital in India over 18 months (March 2021 to August 2022). We included patients >18 years (41 male, 38 female), with ColR and colistin-intermediate (ColI) strains. These patients were assessed for demographics, underlying diseases, antimicrobial treatment, clinical scores (APACHE II, SOFA), and outcome. RESULTS: The presence of a central venous catheter (CVC) was a significantly associated risk factor for ColR infections (p = 0.011). Additionally, prior antibiotic exposure within 3 months (p = 0.049) and CVC presence (p = 0.034) were associated with non-survival among ColR patients. Higher APACHE II and SOFA scores were associated with mortality among ColI patients. The presence of CCI >3 (p = 0.040) and previous history of ICU stay (p = 0.032) emerged as significant factors associated with the isolation of ColR K. pneumoniae among patients with previous history of colistin/polymyxin intake. CONCLUSION: The study highlights the risk factors associated with ColR K. pneumoniae. These findings underscore the need for prudent antimicrobial stewardship.

Source: Indian Journal of Medical Microbiology

DOI: 10.1016/j.ijmmb.2025.100882