Work

Renal G protein-coupled estrogen receptor 1 regulates the epithelial sodium channel promoting natriuresis to a greater extent in females

Year: 2025

Type: article

Abstract: This study identified GPER1 as a sex-specific upstream regulator of ENaC. We found that GPER1 and ENaC were coexpressed in the rat renal tubules in a sex and region-specific manner. Activation of GPER1 inhibited ENaC activity in isolated mouse collecting ducts, whereas deletion of GPER1 from the principal cells caused ENaC hyperactivity to a greater extent in female mice. Our data suggest GPER1 functionally interacts with ENaC in a sex-specific manner to promote natriuresis.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00019.2025

Authors: Victoria L. Nasci, Jean C. Bopassa, Elena Mironova, Megan Rhoads, Ravneet Singh, Dennis P. Buehler, David M. Pollock, Oleh M. Pochynyuk, James D. Stockand, Eman Y. Gohar

Institutions: Vanderbilt University, Vanderbilt University Medical Center, The University of Texas at San Antonio Health Science Center, University of Alabama at Birmingham, UAB Medicine, The University of Texas Health Science Center at Houston

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, University of California, San Diego, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, Division of Diabetes, Endocrinology, and Metabolic Diseases

Awards: G1056151686, G1442900148, G2390096021, Renal Biology and Disease Training Program, G3596569584, G4040257628, G427343587, G5950577451, G6444744614, G7471796285, Physiology of ClC-K2/b Cl- channel in the collecting duct, G9000048202, Pathobiology of Occlusive Vascular Disease

OpenAlex ID: W4410615199

FWCI: 1.26

Cites: 39

Cited by: 5

Related to: 10