Work

Immune-aging at diagnosis determines T-cell recovery in childhood leukemia survivors

Year: 2025

Type: article

Study design: Observational Study

Abstract: We show that T cells in survivors of childhood leukemia exhibit distinct profiles dominated by aging-associated changes and consistent with premature immune aging. Immune profiles during survivorship in biospecimens (n = 251) from uniformly-treated children with B-acute lymphoblastic leukemia recapitulate heterogeneity at diagnosis in individual patients and correlate with genetic-risk subtypes. These data suggest that pre-therapy immune aging may determine variance in immune status during survivorship.

Source: npj Aging

DOI: 10.1038/s41514-025-00233-0

Authors: Kavita M. Dhodapkar, Sharon Castellino, Shivani Kapadia, Maryam I. Azeem, Ava Horvat, Taylor Lawrence, Deborah DeRyckere, Madhav V. Dhodapkar

Institutions: Seattle Children's Hospital, Fred Hutch Cancer Center, Emory University, Children's Healthcare of Atlanta, Winship Cancer Institute

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,690

Funders: Leukemia and Lymphoma Society, Children's Healthcare of Atlanta, National Institutes of Health, National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: B cells in autoimmunity following checkpoint blockade therapy, G1489263424, G1823531124, B cell depletion to prevent autoimmunity, G8162264869, G9000017109, G9000079088

OpenAlex ID: W4410617566

FWCI:

Cites: 8

Cited by:

Related to: 10