Figure 6 from PD-1 Blockade Mitigates Surgery-Induced Immunosuppression and Increases the Efficacy of Photodynamic Therapy for Pleural Mesothelioma
Year: 2025
Type: other
Abstract: PD-1 blockade significantly decreases tumor growth rates in combination with TI/PDT. αPD-1 initiated 1 hour after PDT and continuing 2× weekly for 3 weeks did not significantly alter tumor growth rates. A, In AB12 mice, more than 50% of both PDT alone (n = 14) and PDT/aPD-1 (n = 12) had median survival (time to 400 mm3) greater than 90 days, and no differences between groups were detected (P = 0.56). B, In AE17O mice, median survivals of 33.5 days for PDT (n = 34) and 40 days for PDT/αPD-1 (n = 12) were similar (P = 0.79). C, In AB12 tumor–bearing mice that received TI prior to PDT, αPD-1 significantly decreased the rate of tumor regrowth (P = 0.005), with a median survival >90 days for TI/PDT/αPD-1 (n = 13) and 24-day median survival in TI/PDT (n = 16). TI/PDT/αPD-1 isotype control (n = 13) was also significantly different from TI/PDT/αPD-1 (P = 0.025) and similar to TI/PDT (P = 0.87). D, In AE17O tumor–bearing mice that received TI prior to PDT, αPD-1 also significantly decreased the rate of tumor regrowth (P = 0.025), with a median survival of 20.5 days for TI/PDT (n = 18) and 26 days for TI/PDT/αPD-1 (n = 20). In all tumor responses, vertical dashes indicate animals that were censored due to tumor ulceration or metastasis. Groups treated with an isotype for αPD-1 are plotted in pale orange. Tumor responses were compared using log-rank (Mantel–Cox) tests.
Authors: Gwendolyn M. Cramer, Richard W. Davis, Emmanouil Papasavvas, Astero Klampatsa, Joann M. Miller, Shirron Carter, Ruth Ikpe, Min Yuan, Sandy Widura, R. Sonali Majumdar, Sally McNulty, Mary Putt, Andrew V. Kossenkov, Luis J. Montaner, Sunil Singhal, Edmund K. Moon, Steven M. Albelda, Keith A. Cengel, Theresa M. Busch
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4410618752