Effects of erythropoietin on cardiac morphometry in exercised male and female adolescent rats.
Year: 2025
Type: article
Abstract: epoetin alfa intraperitoneally, four times a week, followed by 30 min of swimming exercise. The post-study measurements demonstrated that EPO administration did not result in notable alterations in crucial parameters, including the left ventricular mass index, left ventricular mass, and left ventricular posterior wall in the context of left ventricular hypertrophy in both genders. However, in female rats, EPO-only group and the combined EPO and exercise group showed significant thinning of the right ventricular wall and interventricular septum indicating potential cardiac dilatation. The results highlight the necessity of considering gender-specific responses when evaluating EPO's cardiovascular effects, particularly concerning the right ventricle, and suggest further investigation into the long-term consequences of these observed changes.
Source: PubMed
Authors: Mehmet Burak Ateş, Gokhan Akcakavak, Ozgur Ozdemir, Mehmet Ozdemir, Ibrahim Bozkurt
Institutions: Selçuk University, Aksaray University, Adnan Menderes University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4410622716