Telangiectasia Macularis Eruptiva Perstans Following Radiotherapy: Atypical Presentation of a Rare Condition
Year: 2025
Type: article
Study design: Case Report
Abstract: Telangiectasia macularis eruptiva perstans (TMEP) is a rare form of cutaneous mastocytosis characterized by telangiectatic macules and plaques. We report an atypical case of TMEP in an 80-year-old female with a history of left invasive lobular carcinoma, previously treated with mastectomy, radiotherapy, and hormonal therapy. The patient presented with a single telangiectatic plaque on the left side of her trunk. Histopathological examination confirmed the diagnosis of TMEP. This case is notable due to the patient's advanced age and the history of extensive cancer treatment, including radiation therapy. The potential association between radiation therapy and the development of mast cell disorders is explored, considering the possible role of radiation-induced skin changes in the pathogenesis of TMEP. This case underscores the importance of considering TMEP in the differential diagnosis of telangiectatic lesions, particularly in patients with a history of malignancy and radiation therapy. Further research is warranted to elucidate the mechanisms linking radiation therapy to mast cell proliferation and activation.
Source: Cureus
DOI: 10.7759/cureus.84675
Authors: Mariam Harb, Anne Theunis, Evelyne Berlingin
Institution: Erasmus Hospital
Language: English
Topic: Mast cells and histamine
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4410628941