Work

Synthetic RNA ligands as activators of type I toxin–antitoxin systems: a novel antimicrobial strategy targeting Helicobacter pylori

Year: 2025

Type: article

Abstract: . This represents an unprecedented antimicrobial strategy based on the use of compounds that are not toxic by themselves but activate the production of an endogenous toxin produced by the bacteria themselves. Finally, this work allowed us to explore new compounds to inhibit RNA-RNA interactions, which also represents an underexplored field of RNA targeting.

Source: Chemical Science

DOI: 10.1039/d5sc01412c

Authors: Céline Martin, Marc Panosetti, Eleonora Tesini, Stéphane Azoulay, Anthony Bugaut, Véronique Sinou, Nadia Patino, Audrey Di Giorgio, Fabien Darfeuille, Maria Duca

Institutions: Centre National de la Recherche Scientifique, Université de Bordeaux, Inserm, Université Côte d'Azur, Aix-Marseille Université, Institut de Chimie de Nice, Acides nucléiques: Régulations naturelles et artificielles

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Agence Nationale de la Recherche

Awards: Therapeutic innovations in antibiotics: focus on the targeting of toxin-antitoxin systems using small-molecule RNA binders, G6803667113

OpenAlex ID: W4410629020

FWCI: 0.522

Cites: 26

Cited by: 2

Related to: 10