Work

Radiation-induced cellular senescence and adaptive response: mechanistic interplay and implications

Year: 2025

Type: article

Abstract: Cellular responses to radiation exposure involve complex and dynamic signaling networks that coordinately regulate cell fate. Senescent cells exhibit irreversible growth arrest and functional alterations, while adaptive response confers cellular protection against subsequent radiation insults. The intricate interplay between the two processes influences radiation resistance and genomic stability, with implications for understanding molecular mechanisms of radiotherapy and cellular stress responses. This review systematically investigates the molecular triggers and signaling pathways underlying radiation-induced cellular senescence and adaptive response, and elucidates the molecular interactions between these phenomena. The findings have significant implications for understanding of cellular stress responses, optimizing radiotherapy protocols, and mitigating radiation-induced cellular dysfunction.

Source: Radiation Medicine and Protection

DOI: 10.1016/j.radmp.2025.05.002

Authors: Haiying Wang, Weijin Zou, Yi Cao

Institution: Soochow University

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000