Work

Predictive value of preoperative serum cytokeratin 19 fragment antigen 21-1(CYFRA 21-1) in surgical resection for colorectal cancer: A retrospective study

Year: 2025

Type: article

Abstract: Objective This study evaluates the potential of cytokeratin 19 fragment antigen 21-1 (CYFRA 21-1) as a prognostic indicator in colorectal cancer (CRC) patients after surgical treatment. Methods A retrospective review examined 456 CRC patients who received surgical intervention at our center from January 2022 through February 2024. Analysis included preoperative biomarkers (CYFRA 21-1, CEA, CA19-9) alongside comprehensive pathological findings. Results The determined optimal threshold values were 4.9 ng/ml for CYFRA 21-1, 29.2 ng/ml for CEA, and 72.8 U/ml for CA19-9. Significant clinical and pathological differences emerged between patients with high versus low CYFRA 21-1, including variations in sex, tumor characteristics, invasion patterns, nodal status, and TNM stage (P = 0.018, <0.001, <0.001, <0.001, 0.002, 0.001, 0.003, respectively). High CYFRA 21-1 (≥4.9 ng/ml) served as an independent predictor for diminished 5-year overall survival (OS). Conclusion Elevated preoperative CYFRA 21-1 represents a significant independent prognostic factor in CRC patients. An integrated predictive model combining CYFRA 21-1, CEA, CA19-9, and TNM staging offers valuable risk stratification capabilities that could enhance surveillance strategies and therapeutic decision-making for CRC patients.

Source: Current Problems in Surgery

DOI: 10.1016/j.cpsurg.2025.101791

Authors: Shuyuan Gu, Shihui Chen, Yuan Chai, Chao Qu, Xuejun Sun, Junhui Yu

Institution: First Affiliated Hospital of Xi'an Jiaotong University

Language: English

Topic: Colorectal Cancer Surgical Treatments

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,780