Work

Total Synthesis of Cardenolides Acospectoside A and Acovenoside B

Year: 2025

Type: article

Abstract: Acospectoside A (1) and acovenoside B (2), two cytotoxic cardenolides extracted from the venomous South African bush Acokanthera oppositifolia, are distinguished by their unique structural motifs of the l-acovenose moiety at C-3 and a 1β-O-acetylated cardenolide aglycone. Here, we report the synthesis of these cardiac glycosides featuring delicate introductions of the 1-O-acetyl group under acid-catalyzed conditions, 14β-OH by Mukaiyama hydration, and a C17-butenolide moiety by Stille coupling.

Source: Molecules

DOI: 10.3390/molecules30112297

Authors: Benzhang Liu, Peng Xu, Biao Yu

Institutions: Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences

Language: English

Topic: Phytochemistry and Bioactive Compounds

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funders: National Natural Science Foundation of China, Chinese Academy of Sciences