Work

Corticosterone induces fatty liver syndrome in chickens via glucocorticoid receptor and inhibition of mitochondrial supercomplex formation

Year: 2025

Type: article

Abstract: This study reveals the pivotal role of GR-mediated transcriptional regulation in stress-induced FLS in chickens. Chronic stress modeled with CORT disrupted mitochondrial SC assembly, impairing electron transport, elevated ROS production, and liver steatosis. Notably, the downregulation of complex I assembly factors ( NDUFAF5, NDUFAF7, and TIMMDC1) and reduced GR binding to NDUFAF5 were key mechanisms. These findings provide new insights into stress-driven mitochondrial dysfunction in broiler FLS.

Source: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI: 10.1152/ajpregu.00313.2024

Authors: Huimin Chen, Ke Zhang, Hui Yu, Ziting Guan, Ruqian Zhao, Lei Wu

Institutions: Oklahoma State University, Nanjing Agricultural University

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: hybrid

Funders: National Natural Science Foundation of China, Natural Science Foundation of Jiangsu Province