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The Synthesis, spectral, molecular docking and antimicrobial studies of some substituted 4-([1,1’-biphenyl]-4-yl) pyrimidine-2(1H)-thiones

Year: 2025

Type: article

Abstract: Some substituted 4-([1,1’-biphenyl]-4-yl)pyrimidine-2(1H)-thione derivatives were synthesized by one-pot three component synthesis reaction of 4-acetyl biphenyl, various substituted aryl aldehydes and thiourea in the presence of sodium hydroxide. In this reaction the obtained yield was more than 85%. The synthesized pyrimidine thiones were characterized by their physical constants, micro-analysis and spectroscopic data. The molecular docking study of these pyrimidinethiones were investigated with protein interaction-affinity measurements. Using the Bauer-Kirby technique, the antimicrobial abilities of synthesized pyrimidinethiones were evaluated.

Source: Indian Journal of Chemistry

DOI: 10.56042/ijc.v64i5.9338

Author: Thirunarayanan G

Institution: Annamalai University

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: VIT University

Award: G742025864