Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetes
Year: 2025
Type: article
Study design: Observational Study
Abstract: Gestational diabetes mellitus (GDM) is linked to an imbalance in gut microbiota composition, which can be transferred to the mother’s offspring. Clostridium butyricum, known for its health benefits in diabetes and allergy, lacks sufficient data regarding its effect on the immune system’s development in the offspring of mothers with GDM. This study assessed antibody responses against C. butyricum T2F3 in children of mothers at risk for GDM, involving 88 children aged 1–6 years. Antibody responses were measured with flow cytometry and immunoblot. Lower IgG median fluorescence intensity (MFI) values and fewer IgA and IgG bands against C. butyricum were detected in children of mothers with GDM. Maternal body mass index was positively associated with children’s IgG MFI and number of IgG bands. Fewer IgA bands were detected in children with higher IgE levels, atopic dermatitis, asthma, and allergic rhinitis. More IgG bands were detected in children with higher anti-β-lactoglobulin IgG levels. Children with autoimmune risk-related HLA-DR3/DQ2.5 had fewer IgA bands, while those with neutral HLA-DR1/DQ5 had higher IgA, but lower IgG MFI. These results indicate that maternal prenatal changes could affect their offspring’s immune response against C. butyricum. Moreover, C. butyricum could have a protective role against allergic sensitization.
Source: Immunological Medicine
Authors: Celeste Peterson, Aili Tagoma, Kristi Alnek, Anu Bärenson, Tamara Vorobjova, Ija Talja, Helis Janson, Anne Kirss, Siiri Kõljalg, Aki Sinkkonen, Marja Irmeli Roslund, Raivo Uibo, the HEDIMED Investigator Group, Eurén Anna, Hyöty Heikki, Kurppa Kalle, Laiho Jutta, Laitinen Olli, Lehtonen Jussi, Lindfors Katri, Lönnrot Maria, Malkamäki Johannes, Numminen Henna, Nurminen Noora, Nykter Matti, Oikarinen Sami, Puustinen Leena, Saarinen Niila, Sioofy-Khojine Amirbabak, Viiri Keijo, Agardh Daniel, Aronsson Carin Andrén, Lundgren Markus, Mäkelä Iida, Romantschuk Martin, Soininen Laura, Lund-Blix Nicolai, Magnus Maria, Rantala Aino-Kaisa, Stene Lars, Størdal Ketil, Tapia German, Elo Laura, Junttila Sini, Lahesmaa Riitta, Lempainen Johanna, Moulder Robert, Rasool Omid, Suomi Tomi, Toppari Jorma, Ullah Ubaid, Veijola Riitta, Peet Aleksandr, Simre Kärt, Tillmann Vallo, Bargagli Elena, Dotta Francesco, Nigi Laura, Sebastiani Guido, Hakola Leena, Kiviranta Hannu, Rantakokko Panu, Virtanen Suvi, Cinek Ondrej, Fronkova Eva, Havlik Jaroslav, Barannik Emilia, Molinier Matthieu, Nevanen Tarja, Pajula Juha, Parmes Eija, Pärkkä Juha, Ranta Jukka, Rökman Jyri, Saviranta Petri, Ylén Peter, Aints Alar, Bärenson Anu, Kirss Anne, Laidmäe Ivo, Tagoma Aili, Uibo Raivo, Vorobjova Tamara, Burr Loïc, Cattaneo Stefano, Chai-Gao Hui, Cristofollini Peter, Generelli Silvia, Paoletti Samantha, Ruth Edith, Berg Gabriele, Wicaksono Wisnu, Hoffman Kristi, Petrosino Joseph, Schmidtmann Daniel, Thiel Rainer, Salo Rosanna, Häme Lauri, Berler Alexander, Karabatea Apostolia, Papadopoulou Korina, Bisgaard Hans, Bønnelykke Klaus, Brandt Sarah, Sevelsted Astrid, Stokholm Jakob, Thorsen Jonathan, Knip Mikael, Roslund Marja, Sinkkonen Aki
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4410695877