Work

An Efficient Synthesis of a Variety of Substituted Pyridine-3-Thiols

Year: 2025

Type: article

Abstract: A practical and convenient method for the synthesis of pyridine-3-thiols using substituted 3-iodopyridines as starting compounds has been developed. Based on the use of thiobenzoic acid as a sulfur donor in a two-step procedure, this approach made it possible to synthesize a number of pyridine-3-thiols with F, Cl, Br, CH3, OCH3 substituents at various positions of the pyridine ring. The procedure presented gives high yields of the target products with a purity of 95% and is suitable for synthesis in tens of grams.

Source: Journal of organic and pharmaceutical chemistry

DOI: 10.24959/ophcj.25.324523

Authors: Oleksandr V. Borysov, Dmytro P. Bohdan

Institutions: National Academy of Sciences of Ukraine, Institute of Organic Chemistry, Enamine (Ukraine)

Language: English

Topic: Synthesis and Reactivity of Sulfur-Containing Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

OpenAlex ID: W4410697352

FWCI:

Cites: 27

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Related to: 10