Evaluating the effect of nutritional support in geriatric inpatients classified by the GLIM criteria
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: In this study, we aimed to explore the impact of nutrition therapy on clinical outcomes for patients classified according to the Global Leadership Initiative on Malnutrition (GLIM) criteria. DESIGN: Prospective, multicenter cohort study. SETTING: This study was conducted from September 2020 to December 2022 across 28 geriatric centers in China. PARTICIPANTS: A total of 862 patients aged ≥65 years were included. INTERVENTION: All participating physicians completed a 6-h training on nutritional support, following international guidelines before the study. Patients had a nutritional risk screening 2002 score ≥3 points within 48 h of admission. Physicians determined specific nutritional support regimens. MEASUREMENTS: GLIM assessments were conducted after enrollment. Nutritional and functional statuses were evaluated at baseline and 90 days after admission. Clinical outcomes-mortality, readmission, new infections, and falls-were documented after 90 days. RESULTS: Compared to 108 patients without malnutrition per the GLIM criteria, 754 malnourished patients showed lower weight, body mass index (BMI), and Mini Nutritional Assessment-Short Form (MNA-SF) scores and significant reductions in grip strength, calf circumference, and Barthel activities of daily living (ADLs) index. The percentage of patients with adequate caloric intake at the 90-day follow-up was 70.7% (n = 533) and 67.6% (n = 73) in the malnutrition and non-malnutrition groups (p = 0.51) and that of patients with adequate protein intake was 65.9% (n = 497) and 58.3% (n = 63), respectively (p = 0.12). Moreover, malnourished patients showed significant improvements in body weight, BMI, MNA-SF scores, calf circumference, and Barthel ADL index compared to those without malnutrition. Malnourished patients also had lower risks of readmission and falls at follow-up. CONCLUSION: Among older inpatients at nutritional risk, those with malnutrition classified according to the GLIM criteria benefited from nutritional support, demonstrating improved BMI, MNA-SF scores, calf circumference, and Barthel ADL index, as well as reduced readmission rates and incidence of falls.
Authors: Shan Jiang, Xiling Chen, Lan Ma, Qihao Guo, Lan Luo, Yuehui Wang, Xuan Qu, Jiaojiao Li, Liping An, Wei Huang, Yonghua Wu, Hongyu Zhang, Cuntai Zhang, Yun Fan, Songbai Zheng, Jian Cao, Xiaohong Liu
Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, Second Affiliated Hospital of Zhengzhou University, Second Affiliated Hospital of Harbin Medical University, Shanghai Jiao Tong University, Shanghai Sixth People's Hospital, Nantong University, Affiliated Hospital of Nantong University, Jilin University, First Hospital of Jilin University, Heilongjiang Provincial Hospital, Tangshan Gongren Hospital, Suzhou Municipal Hospital, Qilu Hospital of Shandong University, Tongji Hospital, Huazhong University of Science and Technology, Beijing Hospital, Shanghai Medical College of Fudan University, Fudan University, Huadong Hospital, Chinese PLA General Hospital, Chinese People's Liberation Army
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,450
Funder: Bethune Charitable Foundation
Award: G5542726538
OpenAlex ID: W4410698833