Work

Squamous Cell Carcinoma in Chronic Cutaneous Leishmaniasis: Coincidence or Malignant Transformation

Year: 2025

Type: article

Abstract: We report the case of a 69-year-old man who developed squamous cell carcinoma (SCC) at the site of a chronic cutaneous leishmaniasis (CL) lesion on the dorsum of his left hand. The lesion had persisted for over three years despite multiple local and systemic treatments. Histopathological examination confirmed the diagnosis of well-differentiated SCC. The patient was lost to follow-up for a year and returned with locally advanced disease, ultimately requiring hand amputation. This case underscores the potential for malignant transformation in chronic leishmaniasis lesions and highlights the need for timely biopsy and long-term monitoring of atypical or non-healing ulcers in endemic regions.

Source: Cureus

DOI: 10.7759/cureus.84720

Authors: Oumaima Bouraqqadi, Sara Elloudi, Meryem Zaryouhi, Laila Chbani, Fatima Zahra Mernissi

Institution: Centre Hospitalier Universitaire Hassan II

Language: English

Topic: Research on Leishmaniasis Studies

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4410715986