Work

Structures and Biological Evaluation of 8,4′-oxyneolignans from the Roots of Platycodon grandifloras

Year: 2025

Type: article

Abstract: Chemical investigations of Platycodon grandiflorus have resulted in the isolation and identification of seven 8,4'-oxyneolignans, including four undescribed compounds (1-4). The structures of these novel compounds were determined using HR-ESI-MS and NMR (1D and 2D) spectroscopic analyses, combined with ECD calculations. The inhibitory activity of these terpenoids against α-glucosidase was also evaluated, and the results revealed that none of the compounds exhibited significant α-glucosidase inhibitory activity at a concentration of 50 μM. Compared with the positive control, all the compounds displayed weak inhibitory activity, with inhibition rates ranging from 1.06% to 7.31%.

Source: Records of Natural Products

DOI: 10.25135/rnp.513.2501.3409

Authors: Lan Ding, Yang Yu, Ling Zhang, Shuangying Gui, Ju-Tao Wang, Baixiang Cai

Institution: Anhui University of Traditional Chinese Medicine

Language: English

Topic: Plant-derived Lignans Synthesis and Bioactivity

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: Chinese Academy of Sciences, Anhui University, State Administration of Traditional Chinese Medicine of the People's Republic of China, Anhui University of Chinese Medicine

OpenAlex ID: W4410719627

FWCI:

Cites:

Cited by:

Related to: 10