Work

Synthesis of a New Bichalcone via Suzuki–Miyaura Coupling Reaction

Year: 2025

Type: article

Abstract: Unlike the wide number of natural biflavonoids, natural bichalcones are a rare and even less studied class. Nevertheless, some of them have proved their interest in the fight against cancer through their cytotoxic activity against human tumor cell lines. The aim of this study was to synthesize a novel bichalcone: 3′,3‴,4,4′,4″,4‴,5′,5‴-octamethoxy-2,3″-bichalcone 1. The most efficient synthetic pathway was the Suzuki–Miyaura reaction between a boronated chalcone and a brominated one.

Source: Molbank

DOI: 10.3390/m2012

Authors: François-Xavier Toublet, Yves Champavier, Aurélie Lévêque, Catherine Fagnère, Christelle Pouget

Institutions: Laboratoire des Agroressources, Biomolécules et Chimie pour l’Innovation en Santé, Université de Limoges, Centre National de la Recherche Scientifique, Inserm, BISCEm - Biologie Intégrative Santé Chimie Environnement

Language: English

Topic: Synthesis of Organic Compounds

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $603

Funders: Centre National de la Recherche Scientifique, Université d'Orléans