Work

Telitacicept for lupus nephritis with BAFF and APRIL double positivity in children: a case report

Year: 2025

Type: article

Abstract: We present a case of pediatric lupus nephritis (LN) with double positivity for BAFF and APRIL, highlighting the efficacy and safety of telitacicept in achieving complete remission. The patient, a 14-year-old Chinese male, presented with severe renal impairment and thrombotic microangiopathy (TMA). Conventional treatments were ineffective, and the patient experienced severe adverse reactions to rituximab. Subsequent treatment with telitacicept and sirolimus led to significant clinical improvement. After 6 months of follow-up, the patient achieved complete remission with an SLEDAI score of 0. This case underscores the potential of precision medicine in LN treatment. Individualized treatment based on pathological mechanisms is necessary, and telitacicept can improve the prognosis of lupus nephritis with good safety.

Source: BMC Pediatrics

DOI: 10.1186/s12887-025-05778-3

Authors: Yang Meng, Meng Ying, Zhao Hongwen, Huang Li, Tang Xiaopeng

Institutions: Army Medical University, Southwest Hospital, Chongqing Maternal and Child Health Hospital

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090