Work

Clinicopathological features and risk factors for local recurrence of breast phyllodes tumors: a dual-center, 12-year, retrospective study

Year: 2025

Type: article

Abstract: Aim: To clarify the risk factors of phyllodes tumor (PT) for local recurrence (LR).Methods: Data from 829 patients with pathologically confirmed benign, borderline and malignant PT of the breast, diagnosed from between 2011 to 2023, were retrieved from the electronic databases of the First Hospital of Jilin University and the First Affiliated Hospital of Xi'an Jiaotong University. Kaplan–Meier curves and Cox proportional-hazards model were conducted to determine the independent risk factors for LR in each group.Results: Of 829 PT patients, 634 (76.5%), 142 (17.1%), and 53 (6.4%) were diagnosed with benign, borderline, and malignant PT, respectively. The LR rates were 5.4%, 9.9%, 13.2%, respectively. The median patient age was 38 years and the median follow-up time was 2.8 (range, 0.2–12.1 years). Of these patients, 13 (2.1%) were diagnosed with benign bilateral PT. Multivariate analysis identified bilateral involvement as a risk factor for LR of benign PT (p = 0.010). Also, univariate analysis identified young age (≤35 years, p = 0.013) as an independent risk factors for LR of borderline PT. Of the patients with malignant PT, multivariate analysis found that breast-conserving surgery (BCS) (p = 0.008) and large tumor size (>50 mm, p = 0.048) were associated with an increased risk for LR of malignant PT.Conclusions: Bilateral PT was a risk factor for LR of benign PT, young age (≤35 years) was associated with poor prognosis of borderline PT, BCS and large tumor size (>50 mm) were high risk factors for LR of malignant PT.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2025.1538523