Work

A rare large-vessel involvement in a patient with a clinical diagnosis of granulomatosis with polyangiitis: A case report

Year: 2025

Type: article

Abstract: A previously healthy 22-year-old female presented with complaints of fatigue, joint pain, headache, fever, and night sweats for several months. She also reported a reddish painful left eye and a rash on her legs 2 months ago. On examination, her blood pressure was elevated at 160/100 mmHg and her lower limb pulses were hardly palpable. On investigation, she had anterior and intermediate uveitis, nasal septal ulcer, proteinuria, positive cytoplasmic anti-neutrophil cytoplasmic antibodies (C-ANCA), and a computed tomography angiography showed multiple abdominal aortic aneurysms and occlusion of both the left common carotid artery and the right superficial femoral artery. Lymph node biopsy showed necrotising granulomatous inflammation. The patient was diagnosed with granulomatosis with polyangiitis (GPA) with large-vessel involvement, which is a rare finding.

Source: Modern Rheumatology Case Reports

DOI: 10.1093/mrcr/rxaf021

Authors: Mona Terkmani, Yasmin Najjar, Fatema Naddaf, Sana Shaikh Torab, Taher Sawas, Sami Albitar

Institution: University of Aleppo

Language: English

Topic: Vasculitis and related conditions

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,071