Work

Phyllofolactones V–X, Bishomoscalaranes With Proangiogenic and Hypolipidemic Activities From Sponge Phyllospongia foliascens

Year: 2025

Type: article

Abstract: ABSTRACT Chemical investigation of the marine sponge Phyllospongia foliascens led to the identification of three new bishomoscalaranes, phyllofolactones V–X (1–3), alongside three known analogs, phyllofolactones M (4) and O–P (5–6). The structures of these bishomoscalaranes were characterized through comprehensive spectroscopic and spectrometric analyses. The in vivo proangiogenic, hypolipidemic, and anti‐heart failure effects, as well as the in vitro antimicrobial, cytotoxic, immunosuppressive, and antioxidant properties of these compounds were assessed. Compounds 3 and 4 displayed significant lipid‐lowering effects at a concentration of 10 µM in the zebrafish model. Meanwhile, compounds 2 and 5 demonstrated strong proangiogenic activity in zebrafish at the identical concentration of 10 µM. Compound 4 exhibited radical‐scavenging activity against both 2,2‐diphenyl‐1‐picrylhydrazyl and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) diammonium saltfree radicals, with IC50 values of 17.27 and 18.90 µM, respectively.

Source: Chemistry & Biodiversity

DOI: 10.1002/cbdv.202500850