Assessing the role of Mac-2 binding protein glycosylation isomer in the management of patients with chronic hepatitis B
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The Mac-2 binding protein glycosylated isomer (M2BPGi) is a serum marker for fibrosis that correlates with the fibrosis stages in various liver diseases. AIM: To examine the M2BPGi's threshold for staging fibrosis in patients with chronic hepatitis B (CHB), and its changes during treatment. METHODS: This was a prospective, longitudinal study. A total of 348 eligible patients were recruited from the Hepatology Department, Medic Medical Center between March 2020 and December 2023. Liver enzyme tests, platelet counts, M2BPGi levels, and FibroScan were conducted at baseline and at 3-month intervals until six months post-treatment. Correlation plots of M2BPGi, FibroScan, and the other parameters were generated. Receiver operating characteristic curves were constructed for M2BPGi and the other parameters to evaluate their performance. RESULTS: M2BPGi levels correlated well with FibroScan results and increased as the fibrosis stage advanced. The median M2BPGi levels at the different stages of fibrosis showed statistically significant differences. The cut-off values of M2BPGi for diagnosing significant fibrosis (F ≥ 2), advanced fibrosis (F3), and cirrhosis (F4) were determined to be 1.08, 1.4, and 1.52, respectively. In the context of fibrosis regression in CHB patients during the first 6-month of treatment, M2BPGi levels appeared to decrease before this pattern occurred in the FibroScan results. CONCLUSION: M2BPGi levels were strongly correlated with FibroScan. M2BPGi can be used to assess liver fibrosis, and to serve as a tool for monitoring fibrosis regression in CHB patients undergoing treatment.
Source: World Journal of Hepatology
Authors: Thuy T T Pham, Dat T Ho, Hai T Phan, Toan B Nguyen, Khue M Nguyen
Institution: Ho Chi Minh City University of Science
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funders: U.S. Department of Veterans Affairs, Bill and Melinda Gates Foundation, Social Science Research Council, United Nations Population Fund, Emory University, Università degli Studi di Napoli Federico II, Harvard University, Cleveland Clinic, Florida International University, Helsingin Yliopisto, Hamad Medical Corporation, Johns Hopkins University, Georgetown University, University of Rochester, Case Western Reserve University, Bournemouth University, University of South Carolina, Moffitt Cancer Center, Jazan University, COMSATS Institute of Information Technology, New Mexico State University, McMaster University, Iran University of Medical Sciences, Università degli Studi di Milano, Eastern Virginia Medical School, Ministerio de Ciencia, Innovación y Universidades, South Eastern Sydney Local Health District, Centres de Recerca de Catalunya, Aksum University, National Authority for Scientific Research and Innovation, Ahmadu Bello University, Trường Đại học Duy Tân, Wollega University, Tribhuvan University, Kasturba Medical College, Manipal, Hamad Bin Khalifa University, Neyshabur University of Medical Sciences, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Imperial College London, University College London, University of Oxford, La Trobe University, Macquarie University, London South Bank University, South African Medical Research Council, National University of Singapore, Amity University, University College Cork, Rijksuniversiteit Groningen, Charles Sturt University, University of Sydney, University of Technology Sydney, Deakin University, Flinders University, University of South Australia, James Cook University, Queensland University of Technology, Curtin University of Technology, Universiteit Utrecht, Public Health England, Ain Shams University, Sharif University of Technology, Yonsei University, Kyung Hee University, Ewha Womans University, Gachon University, Islamic Azad University, Amirkabir University of Technology, Banaras Hindu University, Generalitat de Catalunya, Isfahan University of Medical Sciences, Istituto Superiore di Sanità, Jordan University of Science and Technology, King Abdullah University of Science and Technology, King Abdulaziz University, Khalifa University of Science, Technology and Research, Mazandaran University of Medical Sciences, Shiraz University of Medical Sciences, Tabriz University of Medical Sciences, Università degli Studi di Firenze, Kuwait University, Tehran University of Medical Sciences and Health Services, University of Peshawar, Taipei Medical University, Mashhad University of Medical Sciences, Haramaya University, Chinese University of Hong Kong, Süleyman Demirel Üniversitesi, Nankai University, Jimma University, Shiraz University, Universitair Medisch Centrum Groningen, Birjand University of Medical Sciences, Universidad de Antioquia, Kermanshah University of Medical Sciences, Guilan University of Medical Sciences, Universidade de São Paulo, Göteborgs Universitet, Autoritatea Natională pentru Cercetare Stiintifică, Shahid Beheshti University of Medical Sciences, Bahir Dar University, Università di Bologna, United Arab Emirates University, Oxford University Hospitals NHS Foundation Trust, Universitas Indonesia, Qazvin University of Medical Sciences, University of Dhaka, Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii, Universidade do Porto, Technische Universität Berlin, Wuhan University, Secretaría Nacional de Ciencia, Tecnología e Innovación, Semnan University, University of Cape Town, Arak University of Medical Sciences, Instituto Politécnico do Porto, National Research University Higher School of Economics, Universitatea din București, University of Sulaimani, Universitatea de Medicină şi Farmacie "Carol Davila" Bucureşti, University of Tabriz, University of Gondar, Addis Ababa University, Southeast University, Golestan University of Medical Sciences, Universitas Airlangga, Xiamen University, International Centre for Diarrhoeal Disease Research, Bangladesh, University of Science and Technology of China, National Center of Neurology and Psychiatry, University of Colombo, Peking Union Medical College, Kurdistan University Of Medical Sciences, Frankfurt University of Applied Sciences, Imam Abdulrahman Bin Faisal University, Jahrom University of Medical Sciences, Universitas Padjadjaran, Universitas Syiah Kuala, National Institute for Research in Tuberculosis, Rajshahi University, Universitas Muhammadiyah Surakarta, Moscow Institute of Physics and Technology, Universitas Ahmad Dahlan, Alfaisal University, Pirogov Russian National Research Medical University, Ajman University, Madda Walabu University, Debre Markos University, Dilla University, University of Health and Allied Sciences, Debre Tabor University, University of Veterinary and Animal Sciences, National Institutes of Health, Directorate for Biological Sciences, Samsung, University of Texas Health Science Center at San Antonio, College of Science and Engineering, University of Minnesota, School of Public Health and Family Medicine, University of Cape Town, Medical Research Council, National Health and Medical Research Council, Fundação para a Ciência e a Tecnologia, Gastrointestinal and Liver Diseases Research Center, Centre for Heart Rhythm Disorders, University of Adelaide, Student Research Committee, Tabriz University of Medical Sciences, National Heart, Lung, and Blood Institute, Fogarty International Center, Division of Mathematical Sciences, Division of Human Resource Development, Stanford Cardiovascular Institute, School of Medicine, Stanford University, Institute of Infection and Immunity
OpenAlex ID: W4410735001