Work

Routing immunomodulatory cytokine-encoded mRNAs to the omentum: turning an enemy into an ally in peritoneal metastasis

Year: 2025

Type: editorial

Abstract: Peritoneal metastases remain a significant clinical challenge owing to the immunosuppressive nature of the omentum, which serves as a protective niche for disseminated tumor cells. Our recent study explored the targeted delivery of immunomodulatory cytokine-encoded mRNAs to the omentum, aiming to shift its role from a tumor-supportive site to an immune-activating ally. Our findings highlight the potential of cytokine mRNA delivery as a novel and safe immunotherapeutic strategy for peritoneal metastases.

Source: OncoImmunology

DOI: 10.1080/2162402x.2025.2510998

Authors: Leire Arrizabalaga, Ignacio Melero, Pedro Berraondo, Fernando Aranda

Institutions: Navarre Institute of Health Research, Clinica Universidad de Navarra, University of Oxford, Centro de Investigación Biomédica en Red de Cáncer

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913