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Remarkable healing of a severe wound through surgical debridement, honey medicinal application, amniotic membrane, and bovine collagen powder; A case report study

Year: 2025

Type: article

Abstract: INTRODUCTION AND IMPORTANCE: Treating severe wounds presents considerable challenges in contemporary medicine, requiring novel strategies to improve healing and restore tissue integrity. This study examines the efficacy of a comprehensive approach that combines surgical debridement, honey as a medicinal application, amniotic membrane grafting, and bovine collagen powder. CASE PRESENTATION: 20-year-old male experienced significant injuries to his right hand due to a motor vehicle accident. Initial evaluations showed extensive lacerations and necrotic tissue. After stabilizing his condition, the patient underwent surgical debridement to eliminate non-viable tissue, thereby establishing an optimal healing environment. A structured wound care regimen was then initiated, including the use of honey, amniotic membrane, and bovine collagen. DISCUSSION: The therapy combination demonstrated effectiveness. Surgical debridement reduced the risk of infection and created a healthy wound bed. Honey helped retain moisture and displayed antibacterial properties, leading to a notable decrease in inflammation. The amniotic membrane facilitated cell migration and proliferation, thereby promoting tissue regeneration. Bovine collagen contributed to the structural integrity and cellular adhesion, further enhancing healing outcomes. Throughout the treatment, the patient reported significant pain relief. CONCLUSION: This case highlights the promise of an integrated approach to managing complex wounds. The effective combination of surgical techniques and advanced biological therapies not only adds to the current body of knowledge but also stimulates further investigation into innovative wound care methods.

Source: International Journal of Surgery Case Reports

DOI: 10.1016/j.ijscr.2025.111468

Authors: Mohammad Reza Faramarzi, Mohsen Sayahi, Behnam Babamiri, Navid Faraji, Kamal Rahimi, Salahaddin Ghaderzadeh