3D multi-phase balanced non-steady-state free precession acquisition for multi-parameter mapping
Year: 2025
Type: article
Abstract: Objective This study presents the 3D MP-b-nSSFP sequence for multi-parametric mapping. Methods We evaluate several aspects of the 3D implementation, like the type of RF pulse (selective/non-selective), the readout duration, the undersampling pattern, and the acceleration factor. We use undersampled scans with subspace-constrained reconstruction and extended spiral readouts to achieve clinically acceptable scan times. The repeatability and accuracy of the $$T_1$$ T 1 and $$T_2$$ T 2 maps are compared with a reference technique in phantom and three volunteer scans. Results Compared with selective refocusing pulses, we observe lower bias with non-selective pulses, despite modeling the spatially varying effect of the pulses in the fitting process. $$T_1$$ T 1 and $$T_2$$ T 2 maps obtained from phantom scans were comparable to the nominal values and those from reference scans. $$T_1$$ T 1 values in vivo were underestimated compared to the reference scan. The maps with an acquisition matrix of $$256 \times 256 \times 44$$ 256 × 256 × 44 and resolution $$1 \times 1 \times 3$$ 1 × 1 × 3 $$\text {mm}^3$$ mm 3 were acquired in 11 min. Conclusion We show that 3D MP-b-nSSFP can be used for multi-parameter mapping within clinically acceptable scan time. Phantom scans show results in good agreement with reference scan results. However, the in vivo scan underestimated $$T_1$$ T 1 .
Authors: Riwaj Byanju, Gyula Kotek, Mika W. Vogel, Stefan Klein, Juan A. Hernandez-Tamames, Dirk H. J. Poot
Institutions: Erasmus MC, General Electric (Netherlands)
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,090
Funder: GE Healthcare
OpenAlex ID: W4410745992