Work

Tranexamic Acid Ameliorated Bleeding Tendency in Abdominal Aortic Aneurysm-Induced Chronic Disseminated Intravascular Coagulation

Year: 2025

Type: article

Abstract: An 84-year-old man with a history of cerebral infarction, inoperable abdominal aortic aneurysm (AAA), and chronic kidney disease-related anemia was admitted for rehabilitation. He had experienced recurrent gastrointestinal bleeding before admission, initially attributed to dual antiplatelet therapy. After admission, progressive subcutaneous hemorrhage developed, prompting detailed coagulation-fibrinolysis testing, which confirmed chronic disseminated intravascular coagulation (DIC) (enhanced-fibrinolytic type) secondary to AAA. Given his advanced age and overall condition, oral tranexamic acid was initiated, resulting in hemorrhage improvement and stabilization of coagulation parameters. Retrospective evaluation suggested that prior gastrointestinal bleeding episodes were more likely attributable to chronic DIC. This case highlights the importance of considering chronic DIC in patients with recurrent, unexplained bleeding, even when they have been evaluated by multiple specialists, and suggests that individualized antifibrinolytic therapy, although not standard, may serve as a practical and familiar option for general internists in carefully selected inoperable elderly patients.

Source: Cureus

DOI: 10.7759/cureus.84822

Author: Seiichi Miwa

Institution: Tokoha University Rehabilitation Hospital

Language: English

Topic: Aortic aneurysm repair treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4410746153