Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: To evaluate the potential association between lead, as an environmental toxic agent, and the clinical manifestations of allergic diseases. Methods: As part of a multi-year cross-sectional study, lead levels and immunological parameters were assessed in 418 allergic patients and 92 healthy controls. Biochemical and immunological analyses were performed using modern laboratory techniques (ICP-MS, ELISA, immunofluorescence), and statistical analysis was conducted using STATA 18. Results: Lead concentration was significantly higher in the allergic patient group (BLL >10 µg/dL observed in 72%), especially among children. Levels of IgE, histamine, and anti-IgE, as well as eosinophil counts, were significantly elevated in the allergic group (p < 0.05). Conclusion: Elevated lead levels may be associated with the allergic sensitization process, particularly in pediatric patients, highlighting the need for environmental health protection.
Authors: NANA SHAVLAKADZE, ANA SILAGADZE
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4410747002