Year: 2025
Type: article
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent inflammation and progressive joint destruction. Current therapies primarily rely on general immune suppression, often leading to suboptimal outcomes and significant side effects. To address these challenges, an interleukin-4 (IL-4)-tethered, hyaluronic acid-based hydrogel is developed that withstands repeated mechanical stress in the joint space while fostering an immunomodulatory environment. The immunosuppressive hydrogel promotes anti-inflammatory M2 macrophage polarization, creating an anti-inflammatory microenvironment while preserving cartilage and mitigating joint damage. The mechanical properties of the hydrogel are carefully optimized for injectability and intra-articular application. Its effectiveness is evaluated in a collagen-induced arthritis (CIA) mouse model, demonstrating potential as a localized therapeutic approach. It is believed that this IL-4-tethered hydrogel platform will provide a foundation for the combinatorial treatment of RA and various inflammatory diseases.
Source: Advanced Healthcare Materials
Authors: Woojin Back, Moonkyoung Jeong, Huyen‐Thao Le, Ji‐Ho Park
Institution: Korea Advanced Institute of Science and Technology
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,880
Award: G5736759212
OpenAlex ID: W4410747275