Work

The effect of synbiotic supplementation on anthropometric indices and bone metabolism in postmenopausal women: A double-blinded randomized clinical trial

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Background This study evaluated the effects of synbiotic supplementation on anthropometric indices and bone metabolism in postmenopausal women. Methods In this randomized, double-blind, placebo-controlled trial, 52 postmenopausal women were received synbiotic or placebo for six months. Anthropometric measurements, bone mineral density (BMD), osteoprotegerin (OPG), receptor activator of nuclear factor kappa-Β ligand (RANKL), C-terminal telopeptide of type I collagen (CTX), procollagen type I N-terminal propeptide (P1NP), tartrate-resistant acid phosphatase 5b (TRAP-5b), and bone-specific alkaline phosphatase (BSAP) were assessed. Results Although there were no considerable differences in BMI, fat mass, or BMD between groups, a significant decrease was observed in the synbiotic group regarding visceral fat content ( p = 0.004), TRAP-5b ( p < 0.001), BSAP ( p = 0.003), and CTX ( p = 0.028). No substantial changes were observed in OPG, RANKL, OC, or P1NP ( p > 0.05). Conclusion Synbiotic supplementation significantly reduced visceral fat and markers of bone resorption in postmenopausal women. Clinical trial registration: ChiCTR2300076114.

Source: Journal of Functional Foods

DOI: 10.1016/j.jff.2025.106906

Authors: Gu Yuming, Lu Zhejun, Sun Longyu, Zong Chenyu, Han Qinglin

Institutions: Nantong University, Affiliated Hospital of Nantong University, Åbo Akademi University, Shanghai Jiao Tong University, Ruijin Hospital

Language: English

Topic: Probiotics and Fermented Foods

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800